Warm-water coral reefs are facing unprecedented Anthropogenic driven threats to their continued existence as biodiverse, functional ecosystems upon which hundreds of millions of people rely. Determining the tipping point thresholds of coral reef ecosystems requires robust assessment of multiple stressors and their interactive effects. We draw upon a literature search and the recent Global Tipping Points Revision initiative to consider warm-water coral reef ecosystem tipping point threshold sensitivity. Considering observed and projected stressor impacts we recognise a global mean surface temperature (relative to pre-industrial) tipping point threshold of 1.2 °C (range 0.7–1.5 °C) and an atmospheric CO2 warming threshold of 350 ppm (range 326–400 ppm), whilst acknowledging that interacting stressors, ocean warming response time, overshoot and cascading impacts have yet to be sufficiently assessed but are likely to lower this threshold. These uncertainties around tipping point sensitivities for such a crucially important ecosystem underlines the imperative of robust assessment and, in the case of knowledge gaps, employing a precautionary principle favouring the lower range tipping point values.